­
­
­
­

Inventi Impact: Molecular Pharmacology

Articles

  • Inventi:pmp/33515/20
    Effect and Comparison of Luteolin and Its Derivative Sodium Luteolin-4â??-sulfonate on Adipogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells Through AMPK-Mediated PPARykk Signaling
    Research 2021 : January - March
    Jung Hwan Oh, Fatih Karadeniz, Jung Im Lee, Youngwan Seo, Mi-Soon Jang, Chang-Suk Kong

    Luteolin is a common phytochemical from the flavonoid family with a flavone structure. Studies reported several bioactivities for\nluteolin and similar flavones. Attenuating the increased adipogenesis of bone marrow cells (hBM-MSCs) has been regarded as a\ntherapeutic target against osteoporotic bone disorders. In the present study, the potential roles of luteolin and its sulfonic acid\nderivative luteolin-OSO3Na in regulating adipogenic differentiation of hBM-MSCs were investigated. Adipo-induced cells were\ntreated with or without compounds, and their effect on adipogenesis was evaluated by adipogenic marker levels such as lipid\naccumulation and PPARc pathway activation. Luteolin hindered the adipogenic lipid accumulation in adipo-induced hBMMSCs.\nImmunoblotting and reverse transcription-polymerase chain reaction analysis results indicated that luteolin downregulated\n................................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Oh, Jung Hwan, et al. \"Effect\nand Comparison of Luteolin and Its Derivative Sodium Luteolin-4y-\nsulfonate on Adipogenic Differentiation of Human Bone Marrow-\nDerived Mesenchymal Stem Cells through AMPK-Mediated PPARy\nSignaling.\" Evidence-Based Complementary and Alternative\nMedicine 2020 (2020); https://doi.org/10.1155/2020/8894910;\nhttp://creativecommons.org/licenses/by/4.0/; Some formatting\nelements, header, footer, logos, dates and pagination were\nmodified while adapting this article.\n
    Download Full Text